Haruki Ochi

This study identifies species-specific oxygen sensing as a key factor in limb regeneration, showing that reducing oxygen sensing in amphibians enhances regenerative capacity while mammals require oxygen-sensitive pathways.

The paper shows that the shh limb enhancer MFCS1 is active in patterned limb regeneration in tadpoles but not in hypomorphic regeneration in froglets, suggesting epigenetic regulation is key.

The paper identifies E-box and AP-1 motifs as cooperative regulators of regeneration-response enhancers in zebrafish and Xenopus.

The paper investigates how retinoic acid (RA) controls pax8 expression during Xenopus pronephros development by identifying meis3 and hox genes as downstream regulators.