Can Aztekin

Tissue composition shapes differential skeletal integration strategies during axolotl limb regeneration

The paper shows that tissue composition at the amputation plane influences osteoclast-mediated skeletal resorption and regenerative strategies in axolotl limb regeneration.

Rapid and efficient generation of human 8-cell-like cells for embryo modelling

This paper develops a method to rapidly generate human 8-cell-like cells (ri8CLCs) using small molecules, enabling efficient modeling of early embryogenesis.

Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration

This study identifies species-specific oxygen sensing as a key factor in limb regeneration, showing that reducing oxygen sensing in amphibians enhances regenerative capacity while mammals require oxygen-sensitive pathways.

Specialized signaling centers direct cell fate and spatial organization in a limb organoid model

The paper develops a limb organoid model to study how signaling centers direct cell fate and spatial organization during limb development.

TopoTome: Topology-informed unsupervised segmentation and analysis of 3D images

TopoTome is an unsupervised 3D image segmentation algorithm that outperforms existing methods by using topological data analysis to detect and segment structural features in biological images.

Spotiflow: accurate and efficient spot detection for fluorescence microscopy with deep stereographic flow regression

Spotiflow improves spot detection in microscopy images using deep learning, achieving subpixel accuracy and efficiency across diverse datasets.

Multi-species atlas resolves an axolotl limb development and regeneration paradox

The paper uses a multi-species single-cell atlas to resolve whether axolotls regenerate limbs by re-forming AER cells, finding they do not fully re-form AER but use a novel mesoderm-based program.

AF10 (MLLT10) prevents somatic cell reprogramming through regulation of H3K79 methylation

This study identifies AF10 as a barrier to somatic cell reprogramming by regulating H3K79 methylation, showing that its suppression enhances reprogramming efficiency.

Secreted inhibitors drive the loss of regeneration competence in Xenopus limbs

The paper identifies extrinsic cues from chondrogenic progression that inhibit AER cell formation and limit limb regeneration in Xenopus tadpoles.