Author

Klemen Strle

Tufts UniversityORCID 0000-0002-0109-6791Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Alexander ArvanitisiD· 1 shared Ali A Djarou· 1 shared Allen C. SteereiD· 1 shared Ana Carolina Leao· 1 shared Ashlee M. EarliD· 1 shared Ben KotzeniD· 1 shared Brenda Rosario Perez· 1 shared Dionysios LiverisiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperMicrobiology

Alexander ArvanitisORCID

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Author profile →

2 papers

Recent·Most cited

Development of a durable, memory-driven, CspZ-targeting Lyme disease vaccine by rational adjuvant selection

Miranda McCarty, Sergio A. Hernández, Jill Malfetano, Ana Carolina Leao, María José Villar, Xiuli Yang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Ulrich Strych, María Elena Bottazzi, Utpal Pal, Klemen Strle, Wen‐Hsiang Chen, Yi‐Pin Lin

This study develops a durable Lyme disease vaccine using CspZ-YAC187S antigen with Alum-CpG and Alum-Gal adjuvants, showing long-term protective immunity and memory responses.

bioRxiv · Jan 11, 2026 · PreprintImmunology

Linkage blocks involving multiple replicons organize Borrelia burgdorferi strain variation and influence virulence in Lyme disease

R Laing, Michael Joshua Foster, M. Amine Hassani, Ben Kotzen, Alexander Arvanitis, Weihua Huang, Terrence Shea, Ali A Djarou, Gordon C. Adams, Stephen F. Schaffner, Tjasa Cerar, Lisa M. Freimark, Eva Ružić‐Sabljić, Dionysios Liveris, Radha Iyer, , Jacob E. Lemieux

This study uses long-read assemblies to show that genetic modules across multiple plasmids organize Borrelia burgdorferi strain variation and influence virulence in Lyme disease.

bioRxiv · Jan 29, 2025 · PreprintMicrobiology