Utpal Pal

This study develops a durable Lyme disease vaccine using CspZ-YAC187S antigen with Alum-CpG and Alum-Gal adjuvants, showing long-term protective immunity and memory responses.

This paper demonstrates that FH-Fc constructs can kill Lyme borreliae and reduce infection in vivo by targeting complement evasion mechanisms.

The paper develops a duplex PCR assay to determine the sex and mating status of Ixodes scapularis ticks using DNA sequence markers identified through whole-genome resequencing and restriction site-associated DNA sequencing.

This study demonstrates that structure-based mutagenesis of CspZ-YA improves antigen stability and immunogenicity, supporting its use in Lyme disease vaccine design.

This study identifies and functionally characterizes IsAQP1, an aquaporin in Ixodes scapularis, showing it is a water channel with low glycerol permeability and salivary gland-specific expression.