Author

Jill Malfetano

New York State Department of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:protein structure· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Utpal PaliD· 3 shared Xiuli Yang· 3 shared Yi‐Pin LiniD· 3 shared Jungsoon LeeiD· 2 shared María Elena BottazziiD· 2 shared Ulrich StrychiD· 2 shared Wen‐Hsiang CheniD· 2 shared Zhuyun LiuiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersImmunology

Utpal PalORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Development of a durable, memory-driven, CspZ-targeting Lyme disease vaccine by rational adjuvant selection

Miranda McCarty, Sergio A. Hernández, Jill Malfetano, Ana Carolina Leao, María José Villar, Xiuli Yang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Ulrich Strych, María Elena Bottazzi, Utpal Pal, Klemen Strle, Wen‐Hsiang Chen, Yi‐Pin Lin

This study develops a durable Lyme disease vaccine using CspZ-YAC187S antigen with Alum-CpG and Alum-Gal adjuvants, showing long-term protective immunity and memory responses.

bioRxiv · Jan 11, 2026 · PreprintImmunology

Complement therapeutic Factor H-IgG proteins as pre-exposure prophylaxes against Lyme borreliae infections

Connor W. McKaig, Jill Malfetano, Thi Hai Yen Tran, Xiuli Yang, Utpal Pal, Keith L. Wycoff, Yi‐Pin Lin

This paper demonstrates that FH-Fc constructs can kill Lyme borreliae and reduce infection in vivo by targeting complement evasion mechanisms.

The Journal of Immunology · Aug 22, 2025Peer-reviewedMicrobiology

Mechanistic insights into structure-based design of a Lyme disease subunit vaccine

Kalvis Brangulis, Jill Malfetano, Ashley L. Marcinkiewicz, Alan Wang, Yilin Chen, Jungsoon Lee, Zhuyun Liu, Xiuli Yang, Ulrich Strych, Dagnija Tupiņa, Ināra Akopjana, María Elena Bottazzi, Utpal Pal, Ching-Lin Hsieh, Wen‐Hsiang Chen, Yi‐Pin Lin

This study demonstrates that structure-based mutagenesis of CspZ-YA improves antigen stability and immunogenicity, supporting its use in Lyme disease vaccine design.

Nature Communications · Apr 6, 2025Peer-reviewedImmunology