María Elena Bottazzi

This study develops a durable Lyme disease vaccine using CspZ-YAC187S antigen with Alum-CpG and Alum-Gal adjuvants, showing long-term protective immunity and memory responses.

This study demonstrates that structure-based mutagenesis of CspZ-YA improves antigen stability and immunogenicity, supporting its use in Lyme disease vaccine design.

This study evaluates a SARS-CoV-2 RBD subunit vaccine in mice, showing that adding CpG enhances immune response and neutralizing antibodies against multiple variants.

This paper describes the development of a recombinant SARS-CoV-2 RBD vaccine candidate produced in yeast, showing high purity, stability, and immunogenicity in mice.

The paper presents an improved genome assembly of Trypanosoma cruzi and reveals a unique genomic structure involving subtelomeric regions and retrotransposons contributing to antigenic variation.