Yi‐Pin Lin

The paper identifies marine sulfated glycans that inhibit Borrelia burgdorferi adhesins' binding to heparin/GAGs, with specific inhibitors showing varying potency against different adhesins.

This study develops a durable Lyme disease vaccine using CspZ-YAC187S antigen with Alum-CpG and Alum-Gal adjuvants, showing long-term protective immunity and memory responses.

This paper demonstrates that FH-Fc constructs can kill Lyme borreliae and reduce infection in vivo by targeting complement evasion mechanisms.

This study demonstrates that structure-based mutagenesis of CspZ-YA improves antigen stability and immunogenicity, supporting its use in Lyme disease vaccine design.