Nathan H. Cho

The paper uses microneedle manipulation to show that anaphase spindle midzone bundles transmit force both locally and globally, revealing their mechanical coupling and role in chromosome segregation.

This study investigates how NuMA activates dynein and regulates microtubule dynamics during mitosis using structural and functional analyses.

This study shows that mechanical force causes local damage and remodeling of spindle microtubules, leading to stabilization under force.

This study shows NuMA reinforces the spindle mechanically through microtubule crosslinking, independent of dynein, by bundling microtubules and stabilizing spindle poles under force.

Long-read sequencing with the knock-knock pipeline profiles CRISPR knock-in repair, finding perfect homology-directed repair is often a minority of integration events and mis-integration varies by context.