Andrew P. Carter

This study uses MINFLUX to track yeast dynein stepping dynamics at high resolution, revealing ATP hydrolysis per step and 8 nm steps with transient plus-end movements.

This study determines cryo-EM structures of dynein-dynactin complexes with five adaptors, revealing shared activation mechanisms and adaptor-specific structural features.

The paper uses cryo-ET to reveal that cytoplasmic lattices in mouse embryos are ubiquitin-charged E2-E3 ligase assemblies involved in protein modification during development.

This study investigates how NuMA activates dynein and regulates microtubule dynamics during mitosis using structural and functional analyses.

The paper presents cryo-EM structures of Egl-BicD-RNA complexes to show how diverse mRNAs are selected for subcellular localization through shape, sequence, and structured RNA elements.

This study identifies how Orientia tsutsugamushi uses ScaC to recruit BICD2 for dynein-based motility, revealing a mechanism for bacterial transport within host cells.

This study identifies CDR2 as a dynein adaptor recruited by kinectin to regulate ER sheet organization and shows its role in centrosomal clustering and ER sheet stacking.

This study uses cryo-ET to reveal the structural organization of ciliary rootlets, showing their filamentous architecture and connections to intracellular membranes.

This study determines the cryo-EM structure of dynein-dynactin with LIS1 and JIP3, revealing how these regulators enable complex formation and function.

The paper determines the structure of dynein-dynactin complex with BICDR1 adaptor bound to microtubules, revealing adaptor recruitment mechanism and interactions.

The paper uses cryo-EM to determine the structure of dynactin's shoulder and pointed end, revealing their architecture and subunit interactions.

The paper identifies two factors, Q22YU3 and Q22MS1, that package axonemal outer dynein arms for ciliary targeting in Tetrahymena.

This study shows SARS-CoV-2 infects choroid plexus epithelial cells in brain organoids, disrupts the blood-CSF barrier, and may contribute to neurological complications.

The paper uses cryo-EM to determine the structure of dynein microtubule-binding domains, revealing structural differences between cytoplasmic and axonemal dyneins that may affect microtubule distortion.

The paper shows that adaptors like BICDR1 and HOOK3 recruit two dyneins to dynactin, increasing force and speed compared to BICD2's single dynein recruitment.