Small Molecule Degradation of the microRNA-21 Precursor Rescues Pathogenic Pathways in Cellular Models of Fibrosis
Tenghui Wang, Xueyi Yang, Yeongju Lee, Jin Hyang Song, Jessica L. Childs‐Disney, Joe G. N. Garcia, Matthew David Disney
This study shows that degrading the miR-21 precursor with TGP-21-RiboTAC reduces pathogenic pathways in fibrosis models by reactivating tumor suppressor genes.
ACS Chemical Biology · May 18, 2026Peer-reviewedBiochemistry