Yusuke Nasu

Calcium-independent biosensors for multiplexed in vivo imaging of extracellular lactate dynamics

The paper develops Ca2+-independent lactate biosensors for multiplexed in vivo imaging of extracellular lactate dynamics alongside neuronal activity.

A sensitive orange fluorescent calcium ion indicator for imaging neural activity

The paper introduces OCaMP, an orange fluorescent calcium indicator that improves sensitivity and performance compared to existing green and red indicators for neural imaging.

Astrocyte glucocorticoid receptors mediate sex-specific changes in activity following stress

The paper investigates how stress affects activity levels through interactions between orexin neurons and astrocytes, finding that astrocytic glucocorticoid receptors mediate sex-specific changes in neuronal firing and activity.

Functional and structural profiling of circulation via genetically encoded modular fluorescent probes.

The paper introduces a mouse line for labeling blood and interstitial fluid with fluorescent proteins to study vascular structure and permeability in vivo.

A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes

The paper shows lactate-dependent glycolysis shifts produce D-serine, linking astrocyte metabolism to synaptic and cognitive functions through CB1 receptor activation.

Improved genetically encoded fluorescent biosensors for monitoring of intra- and extracellular L-lactate

This paper develops improved fluorescent biosensors for monitoring extracellular and intracellular L-lactate in mammalian cells, showing enhanced sensitivity and response kinetics.

A genetically encoded fluorescent biosensor for extracellular L-lactate

This paper develops a genetically encoded fluorescent biosensor for extracellular L-lactate and demonstrates its use in imaging in cultured mammalian cells and brain tissue.