Author

Shahin Sayed

Aga Khan University Hospital NairobiORCID 0000-0002-3472-511XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Francis MakokhaiD· 3 shared Alexandra R. HarrisiD· 2 shared John Gitau· 2 shared Stefan AmbsiD· 2 shared Alejandro A. SchäfferiD· 1 shared Andrew Martinez· 1 shared Annet KiraboiD· 1 shared Aravind SrinivasaniD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBioinformatics

Francis MakokhaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single-cell-guided identification of logic-gated antigen combinations for designing effective and safe CAR therapy

Sanna Madan, Tiangen Chang, Alexandra R. Harris, Huaitian Liu, Andrew Martinez, Saugato Rahman Dhruba, Binbin Wang, Padma Sheila Rajagopal, Sanju Sinha, Aravind Srinivasan, Simon Knott, Shahin Sayed, Francis Makokha, Chi‐Ping Day, Gretchen L. Gierach, , Eytan Ruppin

This paper introduces LogiCAR designer, a computational method using single-cell transcriptomics to identify logic-gated antigen combinations for CAR therapy, showing improved efficacy and safety compared to existing approaches.

bioRxiv · Mar 19, 2025 · PreprintBioinformatics

Whole exome-seq and RNA-seq data reveal unique neoantigen profiles in Kenyan breast cancer patients

Godfrey Wagutu, John Gitau, Kennedy Wanjau Mwangi, Mary Murithi, Elias Melly, Alexandra R. Harris, Shahin Sayed, Stefan Ambs, Francis Makokha

The paper identifies unique neoantigen profiles in Kenyan breast cancer patients using whole exome and RNA sequencing data, highlighting patient-specific mutations and HLA associations.

Frontiers in Oncology · Dec 11, 2024Peer-reviewedGenetic & Genomic Medicine

The Association between the JAK-STAT Pathway and Hypertension among Kenyan Women Diagnosed with Breast Cancer

John Gitau, Godfrey Kinyori, Shahin Sayed, Mohammad Saleem, Francis Makokha, Annet Kirabo

This study investigates the association between JAK-STAT pathway gene expression and hypertension in Kenyan women with breast cancer, finding significant correlations between specific genes and blood pressure metrics.

bioRxiv · Jun 7, 2024 · PreprintCancer Biology