Cancer BiologybioRxivPreprint
Fatty acid scavenging enables cancer escape from KRAS inhibition
Zihang Yuan, Bo Lin, Chunlan Wang…·Hua Su
The paper identifies a metabolic adaptation in KRAS-inhibited cancer cells that enables resistance through fatty acid scavenging via ADGRB1-PI3Kγ signaling, and shows targeting this pathway restores sensitivity to KRAS inhibitors.
DOI 10.64898/2026.04.01.715565