Hua Su

The paper identifies a metabolic adaptation in KRAS-inhibited cancer cells that enables resistance through fatty acid scavenging via ADGRB1-PI3Kγ signaling, and shows targeting this pathway restores sensitivity to KRAS inhibitors.

The paper identifies an inflammatory memory mechanism that disables DDR1 degradation, promoting pancreatic cancer growth by preserving DDR1 stability.

The paper shows that loss of FBXO2 promotes hepatocellular carcinoma by stabilizing Hsp47 through SKP2-mediated proteasomal degradation.

This study identifies the transcriptome-wide map of m6A circRNAs in a hypoxic pulmonary hypertension rat model, showing decreased m6A levels and altered circRNA-miRNA-mRNA networks.