Author

Beicheng Sun

Anhui Medical UniversityORCID 0000-0002-8657-7024Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Hua SuiD· 3 shared Bo LiniD· 2 shared Chunlan WangiD· 2 shared Michael KariniD· 2 shared Zihang YuaniD· 2 shared Andrew M. LowyiD· 1 shared Aqiang Mao· 1 shared Baoyu JiaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

Hua SuORCID

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Author profile →

4 papers

Recent·Most cited

Fatty acid scavenging enables cancer escape from KRAS inhibition

Zihang Yuan, Bo Lin, Chunlan Wang, Yingying Miao, Da Zhang, Ziru Meng, Gangqi Wang, Andrew M. Lowy, Michael Karin, F Y Yang, Beicheng Sun, Hua Su

The paper identifies a metabolic adaptation in KRAS-inhibited cancer cells that enables resistance through fatty acid scavenging via ADGRB1-PI3Kγ signaling, and shows targeting this pathway restores sensitivity to KRAS inhibitors.

bioRxiv · Apr 3, 2026 · PreprintCancer Biology

Inflammatory memory disables a DDR1 degradation checkpoint to enable pancreatic cancer growth

Fei Yang, Bo Lin, Zihang Yuan, Yongkang Yuan, Xiaohong Pu, Chunlan Wang, Kosuke Watari, Rongkui Luo, Beicheng Sun, Michael Karin, Hua Su

The paper identifies an inflammatory memory mechanism that disables DDR1 degradation, promoting pancreatic cancer growth by preserving DDR1 stability.

bioRxiv · Apr 3, 2026 · PreprintCancer Biology

Specific Pathogen Free Ten Gene-Edited Pig Donor for Xenotransplantation

Kaixiang Xu, Heng Zhao, Baoyu Jia, Jiaoxiang Wang, Nazar Ali Mohammed Ali Siddig, Muhammad Ameen Jamal, Aqiang Mao, Kai Liu, W. T. K. Cheng, Chang Qing Yang, Taiyun Wei, Feiyan Zhu, Xiaoyin Huo, Deling Jiao, Jianxiong Guo, , Hong‐Jiang Wei

This study generates 10-gene-edited pigs that reduce immune rejection and zoonotic risks for xenotransplantation, showing improved survival in non-human primate recipients.

Protein & Cell · Aug 23, 2025Peer-reviewedImmunology

SKP2-mediated FBXO2 proteasomal degradation drives hepatocellular carcinoma progression via stabilizing Hsp47

Cailin Xue, Fei Yang, Guojian Bao, Jiawu Yan, Rao Fu, Minglu Zhang, Jialu Ding, Jiale Feng, Jianbo Han, Xihu Qin, Hua Su, Beicheng Sun

The paper shows that loss of FBXO2 promotes hepatocellular carcinoma by stabilizing Hsp47 through SKP2-mediated proteasomal degradation.

bioRxiv · Mar 28, 2024 · PreprintCancer Biology