Author

Norbert S. C. Tay

National University of SingaporeORCID 0000-0002-4960-9250Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Anand Devaprasath D. JeyasekharaniD· 1 shared Arvind RaoiD· 1 shared Ashley P. TsangiD· 1 shared Brian J. LaneiD· 1 shared Char Loo TaniD· 1 shared Chartsiam TipgomutiD· 1 shared Claudio TripodoiD· 1 shared Colm KeaneiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Anand Devaprasath D. JeyasekharanORCID

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1 paper

Recent·Most cited

A lipid-laden macrophage niche drives immunosuppression in primary central nervous system lymphoma

Liang Hong, Subhashini Joshi, Min Liu, Shruti Sridhar, Maria Victoria Revuelta, Zi Yan Charmaine Ong, Norbert S. C. Tay, Wei Xian Clemence Lai, Chartsiam Tipgomut, Patrick William Jaynes, Yanfen Peng, Char Loo Tan, Susan Swee‐Shan Hue, Siok-Bian Ng, Sanjay De Mel, , Anand Devaprasath D. Jeyasekharan

This study identifies lipid-laden macrophages as an immunosuppressive niche in PCNSL, validated through spatial transcriptomics and mouse models, and shows SYK inhibition reverses their tumor-supportive activity.

bioRxiv · Sep 1, 2026 · PreprintCancer Biology