Author

Christian M. Grimm

University of OxfordORCID 0000-0002-0177-5559Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:electrophysiology· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Alice LiniD· 1 shared Arnas PetrauskasiD· 1 shared Belinda Warnke· 1 shared Bin LiuiD· 1 shared Carolin GroebeiD· 1 shared Cheng‐Chang CheniD· 1 shared Christian Wahl‐SchottiD· 1 shared Colin Feldmann· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperPhysiology

Alice LinORCID

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3 papers

Recent·Most cited

CCZ1 is a modulator of TPC2 activity and melanoma cell migration

Zhuo Yang, Colin Feldmann, Lina Ouologuem, Alice Lin, Stefanie Fenske, Stylianos Michalakis, Karin Bartel, Michael Schänzler, Christian M. Grimm, Cheng‐Chang Chen, Christian Wahl‐Schott, Martin Biel

This study identifies CCZ1 as a modulator of TPC2 activity and shows its role in regulating melanoma cell migration through interactions with RAB7a.

bioRxiv · Apr 24, 2026 · PreprintPhysiology

TMEM165 replenishes lysosomal calcium stores, protects cells against calcium overload, and mediates calcium-induced lysosomal H+ leakage

Ran Chen, Bin Liu, Dawid Jaślan, Lucija Kucej, Veronika Kudrina, Belinda Warnke, Yvonne Eileen Klingl, Arnas Petrauskas, Sandra Prat Castro, Kenji Maeda, Christian M. Grimm, Marja Jäättelä

This study identifies TMEM165 as a lysosomal calcium importer that prevents calcium overload and regulates lysosomal pH.

Nature Communications · Jun 5, 2025Peer-reviewedCell Biology

Proton selective conductance and gating of lysosomal cation channel TMEM175

Tobias Schulze, Timon Sprave, Carolin Groebe, Jan H. Krumbach, Magnus Behringer, Kay Hamacher, Gerhard Thiel, Christian M. Grimm, Oliver Rauh

This study investigates the proton selectivity and gating mechanism of the lysosomal cation channel TMEM175 using electrophysiology and molecular dynamics simulations.

bioRxiv · Nov 1, 2024Biophysics