Gerhard Thiel

This study functionally classifies HCN1 variants in patients with neurodevelopmental disorders, finding genotype-phenotype correlations and potential therapeutic targets.

The paper introduces a synthetic potassium channel that senses and mitigates oxidative stress by modulating membrane potential in cells and organelles.

This study identifies a recombinant nanobody that specifically activates HCN4 channels and rescues sinus node dysfunction in a patient with a loss-of-function mutation.

This study investigates the proton selectivity and gating mechanism of the lysosomal cation channel TMEM175 using electrophysiology and molecular dynamics simulations.