Author

Paula Stein

National Institutes of HealthORCID 0000-0002-2040-4593Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Carmen J. WilliamsiD· 3 shared Virginia SavyiD· 3 shared Lenka RadonovaiD· 2 shared Bechara SaykaliiD· 1 shared Brian N. PapasiD· 1 shared Carsten Tobias KuenneiD· 1 shared Catherine Nicole Domingo· 1 shared Darko BosnakovskiiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersDevelopmental Biology

Carmen J. WilliamsORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Calcium signals shape metabolic control of H3K27ac and H3K18la to regulate EGA

Virginia Savy, Paula Stein, Don A. Delker, Martin Andres Estermann, Brian N. Papas, Zongli Xu, Lenka Radonova, Carmen J. Williams

The paper shows that calcium signals at fertilization alter metabolic substrates, affecting epigenetic marks H3K27ac and H3K18la, which impact embryo development and offspring health.

bioRxiv · Mar 14, 2025 · PreprintDevelopmental Biology

The homeobox transcription factor DUXBL controls exit from totipotency

María Vega-Sendino, Felipe F. Lüttmann, Teresa Olbrich, Yanpu Chen, Carsten Tobias Kuenne, Paula Stein, Desiree Tillo, Grace I. Carey, Jiasheng Zhong, Virginia Savy, Lenka Radonova, Tianlin Lu, Bechara Saykali, Kee-Pyo Kim, Catherine Nicole Domingo, , Sergio Ruiz

This study identifies DUXBL as a key factor promoting the silencing of the 2C transcriptional program during exit from totipotency.

Nature Genetics · Mar 20, 2024Peer-reviewedDevelopmental Biology

Superovulation does not alter calcium oscillations following fertilization

Virginia Savy, Paula Stein, Min Shi, Carmen J. Williams

This study tests whether superovulation affects calcium oscillations in fertilized eggs and finds no differences in calcium signaling patterns between superovulated and naturally cycling mice.

Frontiers in Cell and Developmental Biology · Nov 4, 2021Peer-reviewedDevelopmental Biology