Laura A. Banaszynski

The paper develops a biosensor to monitor α-ketoglutarate in human cells and identifies a mitochondrial-to-nuclear pathway regulating chromatin methylation.

This study creates inducible EWSR1-FLI1 degron alleles in tumor cell lines to control fusion oncoprotein expression, showing reversible cell cycle arrest and tumor growth suppression in xenografts.

This study identifies TASOR's role in maintaining developmental potential during the transition from naive to primed pluripotency by preventing L1 transposable element activation and subsequent cell death.

The paper shows that G1 phase length regulates H3K27me3 levels in stem and tumor cells, with longer G1 increasing and shorter G1 decreasing H3K27me3.

This study shows H3.3 is important for chromatin accessibility and transcription factor binding at promoters, but not essential for transcription in ESCs, though needed for differentiation.

The paper shows that loss of heterochromatin at ERVs reduces TF binding at euchromatic sites, leading to decreased pluripotency and differentiation.

This study shows ATRX prevents G-quadruplex DNA stress by interacting with the MCM complex and promoting heterochromatin formation via ESET.

This study shows p300 contributes more to H3K27ac at enhancers than CBP in mESCs, and p300 depletion causes more pronounced acetylation loss at enhancers than promoters.