Author

Laura Katharina Sievers

Christian-Albrechts-Universität zu KielORCID 0000-0002-4677-5181Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexandra Klaus‐BergmanniD· 1 shared Arnd HeuseriD· 1 shared Azucena SalasiD· 1 shared Dieter BeuleiD· 1 shared Doménica MarcheseiD· 1 shared Dominik N. MülleriD· 1 shared Eduard BatlleiD· 1 shared Eireen Bartels‐Klein· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Alexandra Klaus‐BergmannORCID

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2 papers

Recent·Most cited

Endothelial YAP/TAZ rewiring under cardiometabolic stress drives sex-divergent vascular remodeling in heart failure with preserved ejection fraction

Alexandra Klaus‐Bergmann, Laura Katharina Sievers, Jakob Versnjak, Katharina Koch, Tomasz J. Nawara, Eireen Bartels‐Klein, Oliver Popp, January Mikolaj Weiner, Katja Meier, Irene Hollfinger, Ilona Kamer, Martin Taube, Arnd Heuser, Tatiana Borodina, Dieter Beule, , Holger Gerhardt

This study identifies endothelial YAP/TAZ signaling as a driver of sex-divergent vascular remodeling in HFpEF, linking cardiometabolic stress to microvascular changes through YAP1 and ESM1.

bioRxiv · May 13, 2026 · PreprintCell Biology

FixNCut: Single-cell genomics through reversible tissue fixation and dissociation

Laura Jiménez-Gracia, Doménica Marchese, Juan Camilo Nieto, Ginevra Caratù, Elisa Melón-Ardanaz, Victòria Gudiño, Sara Roth, Kellie Wise, Natalie K. Ryan, Kirk B. Jensen, Xavier Hernando‐Momblona, Joana P. Bernardes, Florian Tran, Laura Katharina Sievers, Stefan Schreiber, , Luciano Gastón Martelotto

FixNCut is a reversible fixation and dissociation method that preserves RNA integrity and cellular composition in human and mouse tissues, enabling robust single-cell and spatial analyses.

Genome biology · Mar 29, 2024Peer-reviewedBioinformatics