Felix Thoma

RNA-dependent association of the pyruvate dehydrogenase complex with mtDNA-containing assemblies supports mitochondrial translation

This study shows that the pyruvate dehydrogenase complex (PDHc) associates with mtDNA-containing assemblies in yeast, supporting mitochondrial translation through an RNA-dependent mechanism.

Local Mitochondrial Physiology Defined by mtDNA Quality Guides Purifying Selection

This study shows that yeast cells use local mitochondrial physiology to select for functional mtDNA, with purifying selection against specific mtDNA mutations under fermentative conditions.

Delayed protein translocation protects mitochondria against toxic CAT-tailed proteins

The paper identifies Pth2 as a key player in mitoRQC by modulating protein translocation and shows that delayed translocation protects mitochondria from toxic CAT-tailed proteins.

YeastMate: Neural network-assisted segmentation of mating and budding events in S. cerevisiae

YeastMate automates detection and segmentation of mating and budding events in S. cerevisiae cells using a deep learning model based on Mask R-CNN.