Johannes M. Hagen

This study shows that the pyruvate dehydrogenase complex (PDHc) associates with mtDNA-containing assemblies in yeast, supporting mitochondrial translation through an RNA-dependent mechanism.

The paper identifies the cohibitin complex, including Aim11, as a quality control factor that supports TIM22-mediated insertion of carrier proteins into the mitochondrial inner membrane.

This study shows that yeast cells use local mitochondrial physiology to select for functional mtDNA, with purifying selection against specific mtDNA mutations under fermentative conditions.