Author

Simon Schrott

Ludwig-Maximilians-Universität MünchenORCID 0000-0002-9449-5248Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:yeast· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Christof OsmaniD· 2 shared Serena SchwenkertiD· 2 shared Charlotte Gerle· 1 shared Felix ThomaiD· 1 shared Giada MarinoiD· 1 shared Ignasi FornéiD· 1 shared Ilaria Marafelli· 1 shared Johannes M. HageniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Christof OsmanORCID

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2 papers

Recent·Most cited

RNA-dependent association of the pyruvate dehydrogenase complex with mtDNA-containing assemblies supports mitochondrial translation

Johannes M. Hagen, Nupur Sharma, Felix Thoma, Veronika Iskra, Serena Schwenkert, Simon Schrott, Ignasi Forné, Julia Weisenseel, Mengqiao Yang, Nadja Lebedeva, Christof Osman

This study shows that the pyruvate dehydrogenase complex (PDHc) associates with mtDNA-containing assemblies in yeast, supporting mitochondrial translation through an RNA-dependent mechanism.

bioRxiv · Aug 27, 2026 · PreprintCell Biology

Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number

Simon Schrott, Ilaria Marafelli, Charlotte Gerle, Sebastian Bibinger, Lea Bertgen, Giada Marino, Serena Schwenkert, Romina Rathberger, Johannes M. Herrmann, Christof Osman

This study identifies Mrx6's role in regulating mtDNA copy number through its interaction with Pim1 and Mam33, revealing a mechanism involving substrate specificity and protein stability.

Nucleic Acids Research · Jan 14, 2026Peer-reviewedCell Biology