Christof Osman

This study shows that the pyruvate dehydrogenase complex (PDHc) associates with mtDNA-containing assemblies in yeast, supporting mitochondrial translation through an RNA-dependent mechanism.

This study identifies Mrx6's role in regulating mtDNA copy number through its interaction with Pim1 and Mam33, revealing a mechanism involving substrate specificity and protein stability.

The paper identifies the cohibitin complex, including Aim11, as a quality control factor that supports TIM22-mediated insertion of carrier proteins into the mitochondrial inner membrane.

This study shows that yeast cells use local mitochondrial physiology to select for functional mtDNA, with purifying selection against specific mtDNA mutations under fermentative conditions.

The paper identifies Pth2 as a key player in mitoRQC by modulating protein translocation and shows that delayed translocation protects mitochondria from toxic CAT-tailed proteins.

YeastMate automates detection and segmentation of mating and budding events in S. cerevisiae cells using a deep learning model based on Mask R-CNN.