Author

Ruosen Xie

University of Wisconsin–MadisonORCID 0000-0002-0249-0002Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Shaoqin GongiD· 3 shared Krishanu SahaiD· 2 shared Yuyuan Wang· 2 shared Amr A. AbdeeniD· 1 shared Bikash Ranjan PattnaikiD· 1 shared Cathleen M. LutziD· 1 shared David M. GammiD· 1 shared Diana Marcela TabimaiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Shaoqin GongORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Genome-Wide CRISPR Screening Identifies Cellular Factors Controlling Nonviral Genome Editing Efficiency

Shivani Saxena, Meha Kabra, Amr A. Abdeen, Diana Marcela Tabima, Divya Sinha, Piper A. Rawding, Min Zhu, Ruosen Xie, Tanvi Kulkarni, Giovanni M. Hanstad, Maria A. Fernandez Zepeda, David M. Gamm, Bikash Ranjan Pattnaik, Shaoqin Gong, Krishanu Saha

The paper uses CRISPR screening to identify genes that enhance nonviral genome editing efficiency in human cells, finding six genes that increase editing efficiency by up to five-fold.

Nature Communications · Aug 13, 2026Peer-reviewedGenomics

Overcoming the Blood-Brain Barrier for Gene Therapy via Systemic Administration of GSH-Responsive Silica Nanocapsules

Yuyuan Wang, Xiuxiu Wang, Ruosen Xie, Jacobus C. Burger, Yao Tong, Shaoqin Gong

This study develops GSH-responsive silica nanocapsules for systemic delivery of CRISPR components across the blood-brain barrier, achieving gene editing in the brain.

Advanced Materials · Nov 29, 2022Peer-reviewedNeuroscience

Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins

Jeanette M. Metzger, Yuyuan Wang, Samuel S. Neuman, Kathy J. Snow, Stephen A. Murray, Cathleen M. Lutz, Viktoriya Bondarenko, Jesi Felton, Kirstan Gimse, Ruosen Xie, Dongdong Li, Yi Zhao, Matthew T. Flowers, Heather A. Simmons, Subhojit Roy, , Shaoqin Gong

This study develops non-viral nanocapsules for in vivo CRISPR-Cas9 delivery to edit neuronal DNA in mice, achieving efficient and safe genome editing in specific neuron types.

bioRxiv · Jul 24, 2022Neuroscience