Genetic compensation is triggered by mutant mRNA degradation
Mohamed A. El-Brolosy, Zacharias Kontarakis, Andrea Rossi, Carsten Tobias Kuenne, Stefan Günther, Nana Fukuda, Khrievono Kikhi, Giulia L. M. Boezio, Carter M. Takacs, Shih-Lei Lai, Ryuichi Fukuda, Claudia Gerri, Antonio J. Giráldez, Didier Y. R. Stainier
The paper shows that mutant mRNA degradation triggers transcriptional adaptation in zebrafish and mouse, leading to upregulation of related genes.
Nature · Apr 3, 2019Peer-reviewedGenetics