HIV-Induced Sialoglycans on Infected Cells Promote Immune Evasion from Myeloid Cell-Mediated Killing
Shalini Thakur Singh, S. M. Shamsul Islam, Rui Liu, Opeyemi S. Adeniji, Lacy M. Simons, Pratima Saini, Hiroaki Tateno, Ali Danesh, Paul W. Denton, Leila B. Giron, Richard Brad Jones, Judd F. Hultquist, Han Xiao, Mohamed Abdel‐Mohsen
This study shows HIV increases sialoglycan expression to engage Siglecs on myeloid cells, promoting immune evasion, and demonstrates that disrupting these interactions enhances immune killing of infected cells.
Nature Communications · Dec 13, 2025Peer-reviewedImmunology