Author

Pratima Saini

Northwestern UniversityORCID 0000-0002-4541-3250Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Assay:imaging· 1

Frequent Co-Authors

Hiroaki TatenoiD· 2 shared Judd F. HultquistiD· 2 shared Lacy M. SimonsiD· 2 shared Mohamed Abdel‐MohseniD· 2 shared Ali DaneshiD· 1 shared Amanda Pires BonfantiiD· 1 shared Gauri MirjiiD· 1 shared Han XiaoiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Hiroaki TatenoORCID

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2 papers

Recent·Most cited

HIV-Induced Sialoglycans on Infected Cells Promote Immune Evasion from Myeloid Cell-Mediated Killing

Shalini Thakur Singh, S. M. Shamsul Islam, Rui Liu, Opeyemi S. Adeniji, Lacy M. Simons, Pratima Saini, Hiroaki Tateno, Ali Danesh, Paul W. Denton, Leila B. Giron, Richard Brad Jones, Judd F. Hultquist, Han Xiao, Mohamed Abdel‐Mohsen

This study shows HIV increases sialoglycan expression to engage Siglecs on myeloid cells, promoting immune evasion, and demonstrates that disrupting these interactions enhances immune killing of infected cells.

Nature Communications · Dec 13, 2025Peer-reviewedImmunology

Targeting Siglec-10/α3β1 Integrin Interactions Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer

Pratima Saini, Gauri Mirji, S M Shamsul Islam, Lacy M. Simons, Sajad Ahmed Bhat, Amanda Pires Bonfanti, Kar Muthumani, Priyesh Agrawal, Joel A. Cassel, Hsin‐Yao Tang, Hiroaki Tateno, Rugang Zhang, Judd F. Hultquist, Rahul Suresh Shinde, Mohamed Abdel‐Mohsen

This paper identifies Siglec-10/α3β1 integrin interactions as a mechanism suppressing macrophage phagocytosis in PDAC and shows that targeting these interactions enhances anti-tumor immunity.

Cancer Research · Nov 3, 2025Peer-reviewedImmunology