Lacy M. Simons

This study investigates RSV clades associated with prophylactic breakthrough infections in pediatric transmission clusters and finds that clade associations are driven by transmission dynamics rather than resistance.

This study shows HIV increases sialoglycan expression to engage Siglecs on myeloid cells, promoting immune evasion, and demonstrates that disrupting these interactions enhances immune killing of infected cells.

This study investigates the role of m6A machinery in HIV-1 replication in primary CD4+ T cells, finding that auxiliary m6A writer complex members and the reader YTHDF2 significantly impact viral replication, while catalytic core components have minimal effect.

This paper identifies Siglec-10/α3β1 integrin interactions as a mechanism suppressing macrophage phagocytosis in PDAC and shows that targeting these interactions enhances anti-tumor immunity.

This paper shows that inhibiting the Super Elongation Complex (SEC) with KL-2 increases HIV-1 transcription and reactivates latent virus, especially when combined with other latency reversing agents.

The paper examines alveolar T cell responses in SARS-CoV-2 pneumonia patients, finding that early interferon signaling and targeting of structural proteins correlate with better clinical outcomes.

This study identifies critical human host factors involved in SARS-CoV-2 multicycle replication through a genome-scale siRNA screen and validates potential antiviral targets.

The paper identifies a two-factor authentication mechanism used by the innate immune system to detect low-abundance HIV-1 DNA through PQBP1-mediated capsid recognition and cGAS recruitment.