Judd F. Hultquist

This study identifies a tissue virus microenvironment with stress responses that supports SIV persistence, contrasting with transient reservoirs that show immune activity.

This study identifies APOBEC3G splicing defects in nonhuman primates that lead to different viral mutation profiles compared to humans.

This study shows HIV-1 infected immune cells alter cervical cancer pathways through paracrine signals, with upregulated PI3K-AKT and interferon-stimulated genes.

This study investigates RSV clades associated with prophylactic breakthrough infections in pediatric transmission clusters and finds that clade associations are driven by transmission dynamics rather than resistance.

This study shows HIV increases sialoglycan expression to engage Siglecs on myeloid cells, promoting immune evasion, and demonstrates that disrupting these interactions enhances immune killing of infected cells.

This study identifies phosphoregulation of nuclear protein complexes by HIV-1 latency-reversing agents, revealing shared mechanisms across different LRAs.

This study investigates the role of m6A machinery in HIV-1 replication in primary CD4+ T cells, finding that auxiliary m6A writer complex members and the reader YTHDF2 significantly impact viral replication, while catalytic core components have minimal effect.

This paper identifies Siglec-10/α3β1 integrin interactions as a mechanism suppressing macrophage phagocytosis in PDAC and shows that targeting these interactions enhances anti-tumor immunity.

This paper describes the discovery of new coronavirus MPro inhibitors with improved pharmacokinetics, broad-spectrum antiviral activity, and superior in vivo efficacy compared to existing drugs.

This study shows CPSF6 promotes HIV-1 preintegration complex function by enhancing viral DNA integration into gene-dense regions and restoring integration activity when added back to mutant cells.

This paper shows that inhibiting the Super Elongation Complex (SEC) with KL-2 increases HIV-1 transcription and reactivates latent virus, especially when combined with other latency reversing agents.

The paper examines alveolar T cell responses in SARS-CoV-2 pneumonia patients, finding that early interferon signaling and targeting of structural proteins correlate with better clinical outcomes.

This study identifies critical human host factors involved in SARS-CoV-2 multicycle replication through a genome-scale siRNA screen and validates potential antiviral targets.

The paper identifies a two-factor authentication mechanism used by the innate immune system to detect low-abundance HIV-1 DNA through PQBP1-mediated capsid recognition and cGAS recruitment.

This paper describes a method to efficiently generate genetically modified primary human myeloid cells using CRISPR-Cas9 RNP nucleofection, demonstrating its utility in studying HIV-1 infection and myeloid cell biology.

This study systematically characterizes genome editing in primary T cells, identifies proximal genomic insertions, and develops a machine learning model to predict CRISPR-Cas9 DNA repair outcomes.

The paper describes a CRISPR-Cas9 platform for editing primary CD4+ T cells to study HIV host factors, enabling high-throughput gene manipulation and downstream analysis.