This study identifies Rdh10 as a key regulator of retinoic acid signaling that controls neural crest cell migration during enteric nervous system formation, leading to intestinal aganglionosis in its absence.

bioRxiv · Jan 23, 2025 · PreprintDevelopmental Biology

Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia-reperfusion injury

Can Tan, Pieter R. Norden, Wei Yu, Ting Liu, Naoto Ujiie, Sun Kyong Lee, Xiaocai Yan, Yaryna Dyakiv, Kazushi Aoto, Sagrario Ortega, Isabelle G. De Plaen, Venkatesh Sampath, Tsutomu Kume

This study identifies FOXC1 and FOXC2 as essential regulators of intestinal regeneration after ischemia-reperfusion injury by promoting paracrine signaling from endothelial cells.

EMBO Reports · May 8, 2023Peer-reviewedMolecular Biology

Differential roles of neural crest- and endothelial-derived FOXC2 in trabecular meshwork and Schlemms Canal in glaucomatous pathology

Pieter R. Norden, Lisa Beckmann, Raymond S. Fang, Naoto Ujiie, Zhen Cai, Xian Zhang, Junghun Kweon, Ting Liu, Kazushi Aoto, Susan E. Quaggin, Hao F. Zhang, Tsutomu Kume

The paper investigates the role of FOXC2 in neural crest- and endothelial-derived cells in the trabecular meshwork and Schlemms Canal, showing its importance in development and maintenance of the aqueous humor outflow pathway in glaucoma.

bioRxiv · Feb 20, 2022 · PreprintDevelopmental Biology