Paul A. Trainor

This study shows that loss of polr1c in zebrafish causes reduced myelination and craniofacial defects, with Tp53 pathway activation but no apoptosis in oligodendrocyte precursors.

This study shows that Med23 in endothelial cells is critical for vascular patterning and intramembranous ossification, with HIF1α-Vegf signaling playing a key role in craniofacial development.

This study shows retinoid signaling specifies frontonasal identity and represses maxillary identity in cranial neural crest cells during facial development in mice.

The paper shows that epiblast lumenogenesis occurs in veiled chameleons, a non-avian reptile, before anterior-posterior patterning, challenging the view that it is a mammalian-specific trait.

This paper develops a cryopreservation method for peri-gastrulation squamate embryos using veiled chameleons, optimized with DMSO and non-penetrating cryoprotectants for fieldwork adaptation.

This study identifies NR6A1 as a critical regulator of mammalian neural crest cell specification, formation, and survival through loss-of-function experiments and multiomic analyses.

This study shows that loss of SPECC1L in cranial neural crest cells causes increased Hedgehog signaling and craniofacial defects similar to human syndrome.

The paper describes 10 stages of oogenesis in the brown anole, showing conservation within iguanids and providing a framework for functional studies and gene-editing.

The paper investigates morphogenesis in lizard lungs, finding that stress ball morphogenesis is conserved but luminal inflation varies, with apical constriction contributing to transitional chambers in veiled chameleons.

This study defines 26 developmental stages of pre-oviposition development in the brown anole, revealing divergence from chicken embryogenesis and providing insights into organ system morphogenesis.

This study identifies Rdh10 as a key regulator of retinoic acid signaling that controls neural crest cell migration during enteric nervous system formation, leading to intestinal aganglionosis in its absence.

This study presents a chromosome-scale genome assembly of the veiled chameleon, revealing insights into reptile evolution and developmental mechanisms.

The paper traces the evolutionary history of EGF-CFC proteins across species, showing gene expansion, specialization, and chromosomal translocation in mammals.

The paper identifies and characterizes intermediate states during neural crest cell epithelial to mesenchymal transition and delamination using single-cell RNA sequencing.

The paper identifies a novel mechanism of neural crest cell delamination through cell extrusion, revealing PIEZO1's role in this process in mouse embryos.

The paper identifies a transient double basement membrane midline barrier in the chicken embryo that separates left and right sides of the dorsal mesentery during gut development.

This study shows veiled chameleon embryos lack motile cilia in the L-R organizer and express two Nodal paralogs, revealing a novel mechanism for left-right asymmetry evolution.

The paper shows that rRNA transcription by Pol I is essential for nucleolar structure and liquid-liquid phase separation in mouse embryos.

The paper shows that disruptions in Pol I rRNA transcription specifically affect craniofacial development by causing NCC apoptosis and craniofacial anomalies in mice.

This study identifies Nr6a1 as a master regulator of trunk-specific axial development in mice, controlling elongation, segmentation, and lineage allocation through Hox gene regulation and gene regulatory networks.

This study shows that Nucleolin loss-of-function in zebrafish causes craniofacial anomalies by disrupting Fgf signaling and rRNA synthesis.

The paper examines ocular shape changes during development in two foveated reptiles, finding asymmetric elongation and retraction linked to fovea formation and photoreceptor packing.

The paper investigates how Hoxa2 specifies axial identity in mouse cranial neural crest cells using RNAseq, finding that Hoxa2-/- mutants show PA2 NCCs retaining PA2 signature without strong PA1 upregulation.