Sagrario Ortega

Cyclin Y Overexpression Drives a Fatal Metabolic Syndrome via Defective Glucose Homeostasis

This study shows that CCNY overexpression causes a fatal metabolic syndrome by disrupting glucose homeostasis and inducing a Warburg-like metabolic shift.

A common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice

This paper shows a CTRB2 deletion variant increases pancreatic cancer risk by causing ER stress and inflammation in mice, using a new genetic model.

The mechanoreceptor PIEZO1 is a novel oncogene in glioma by promoting astrocyte reactivity

This study identifies PIEZO1 as an oncogene in glioma that promotes astrocyte reactivity and is associated with worse prognosis in male patients.

miR-203 controls developmental timing and early fate restriction during preimplantation embryogenesis

This study identifies miR-203 as a regulator of developmental timing and cell fate restriction during the totipotency to pluripotency transition in mouse embryos using genetically engineered models and single-cell RNA sequencing.

Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia-reperfusion injury

This study identifies FOXC1 and FOXC2 as essential regulators of intestinal regeneration after ischemia-reperfusion injury by promoting paracrine signaling from endothelial cells.

HASTER is a transcriptional stabilizer of HNF1A

This study identifies HASTER, a lncRNA that stabilizes HNF1A expression through cis-regulatory mechanisms, and shows its disruption leads to diabetes.

HNF1A recruits UTX to activate a differentiation program that suppresses pancreatic cancer

This study shows HNF1A recruits UTX to activate a differentiation program that suppresses pancreatic cancer by remodeling enhancers and inhibiting oncogenic pathways.