Author

James C. Otto

Duke UniversityORCID 0000-0002-4552-1171Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Kevin W. SoutherlandiD· 3 shared Christopher D. KontosiD· 2 shared Kaileen FeiiD· 2 shared Lindsey A. OlivereiD· 2 shared Qunsheng Dai· 2 shared Yarui DiaoiD· 2 shared Yueyuan XuiD· 2 shared Alonso TapiaiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersGenomics

Kevin W. SoutherlandORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic Response

Naseeb Kaur Malhi, Yingjun Luo, Muxi Chen, Xiaofang Tang, Dongqiang Yuan, Rahuljeet Singh Chadha, Alonso Tapia, Shufan Yin, Xuejing Liu, Meirigeng Qi, Marpadga A. Reddy, Jiawei Sun, James C. Otto, Lu Wei, John P. Cooke, , Zhen Bouman Chen

This study maps endothelial-macrophage interactions in diabetic vasculature using single-cell and spatial transcriptomics, identifying TREM2 as a key driver of vascular inflammation and ischemic response in diabetes.

Science Translational Medicine · Apr 22, 2026Peer-reviewedCell Biology

Vcam1+ Fibro-adipogenic Progenitors Mark Fatty Infiltration in Chronic Limb Threatening Ischemia

Qunsheng Dai, Changxin Wan, Yueyuan Xu, Kaileen Fei, Lindsey A. Olivere, Hana S. Shafique, Shaghayegh Sadeghmousavi, Camryn L. Johnson, Brianna Garrett, Leo Akers, Derek Peters, James C. Otto, Christopher D. Kontos, Zhiceng Ji, Yarui Diao, Kevin W. Southerland

The paper identifies Vcam1+ fibro-adipogenic progenitors as markers of fatty infiltration in chronic limb threatening ischemia using single-cell transcriptomics in mouse models.

JVS Vascular Science · Jan 1, 2025Peer-reviewedGenomics

Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cells

Kevin W. Southerland, Yueyuan Xu, Derek Peters, Xiaolin Wei, Xin Lin, Yu Xiang, Kaileen Fei, Lindsey A. Olivere, Jeremy M. Morowitz, James C. Otto, Qunsheng Dai, Christopher D. Kontos, Yarui Diao

This study identifies pro-inflammatory macrophages as a key factor impairing skeletal muscle regeneration in ischemic-damaged limbs by inducing premature differentiation of satellite cells.

Genome Medicine · Nov 10, 2023Peer-reviewedGenomics