Fc-independent SARS-CoV-2 infection-enhancing antibodies decouple N-terminal and receptor-binding domains by cross-linking neighboring spikes
Floris J. van Eerden, Songling Li, Tina Lusiany, Hendra Saputra Ismanto, Tohru Terada, Christoph Gerle, Kanako Akamatsu, Mika Hirose, Fuminori Sugihara, David Virya Chen, Jun-ichi Kishikawa, Takayuki Kato, Yafei Liu, Masato Okada, Hisashi Arase, Daron M. Standley
This study shows that certain SARS-CoV-2 antibodies enhance infection by cross-linking spike proteins, causing NTD-RBD domain decoupling without needing the Fc region.
bioRxiv · Aug 21, 2024 · PreprintMolecular Biology