Author

Jonathan Backer

Albert Einstein College of MedicineORCID 0000-0002-0360-5692Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Abdullah AldehaimaniD· 1 shared Adam HaimowitziD· 1 shared Adriana Levine· 1 shared Adrien LugariiD· 1 shared Afaque A. MominiD· 1 shared Anandsukeerthi SandholuiD· 1 shared Anne R. BresnickiD· 1 shared Haiyan WuiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

Abdullah AldehaimanORCID

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2 papers

Recent·Most cited

BiochemistryCommunications BiologyPeer-reviewedJan 19, 2026

Functional selection in SH3-mediated activation of the PI3 kinase

Safia Aljedani, Anandsukeerthi Sandholu, Abdullah Aldehaiman…·Stefan T. Arold

This study identifies how SH3 domains activate PI3K by engaging in tertiary interactions with p85, revealing a mechanism for controlling activation through functional selection.

2 citations

experimental assaybiophysical modeling

Cancer BiologybioRxivPreprintSep 10, 2024

Platelet PI3Kβ regulates breast cancer metastasis

Ryan C Graff, Adam Haimowitz, Jennifer T. Aguilan…·Jonathan Backer

This study shows that platelet PI3Kβ promotes breast cancer metastasis by enhancing tumor cell invasion and signaling pathways, suggesting it as a therapeutic target.

3 citations

mousebulk RNA-seq