Chromatin state barriers enforce an irreversible mammalian cell fate decision
Mario Andres Blanco, David B. Sykes, Lei Gu, Mengjun Wu, Ricardo Petroni, Rahul Karnik, Mathias J. Wawer, Joshua Rico, Haitao Li, William D. Jacobus, Ashwini Jambhekar, Sihem Cheloufi, Alexander Meissner, Konrad Hochedlinger, David T. Scadden, Yang Shi
The paper identifies a point of irreversible commitment in granulocytic differentiation and shows how chromatin state dynamics and transcription factor feedback loops influence this decision.
Cell Reports · Nov 1, 2021Peer-reviewedMolecular Biology