Stephen T. Smale

Cardiomyocyte-specific loss of Smyd5 leads to a robust activation of inflammatory signaling and heart failure in mice.

This study shows that loss of Smyd5 in cardiomyocytes causes inflammation and heart failure in mice by reducing H4K20me3 and increasing Il-6 expression.

Examining NFκB Genomic Interactions by ChIP-seq and CUT&Tag

This study compares ChIP-seq and CUT&Tag for NFκB transcription factor genomic interactions, showing how experimental conditions affect detected interactions and their functional relevance.

Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation

The paper shows that alternative splicing of DPF2, regulated by PTBP1, affects chromatin organization and transcriptional regulation during stem cell maintenance and neuronal differentiation.

Dissection of acute stimulus-inducible nucleosome remodeling in mammalian cells

The paper develops a framework to analyze nucleosome remodeling in response to stimuli and finds that remodeling preferentially affects poorly positioned nucleosomes at enhancers.

Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPS cells

This study compares OSKM reprogramming factor binding in human and mouse fibroblasts, finding conserved mechanisms and species-specific differences in target sites and regulatory networks.