Author

Yang Mei

Hunan UniversityORCID 0000-0002-0432-2897Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:proteomics· 1

Frequent Co-Authors

Hanqi LiuiD· 2 shared Lu LiuiD· 2 shared Manxi Zheng· 2 shared Qinlu Peng· 2 shared Suxuan LiuiD· 2 shared Xinshu Xie· 2 shared Xuezhen MaiD· 2 shared Zhejuan Shen· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

Hanqi LiuORCID

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3 papers

Recent·Most cited

FASN Inactivation-induced Progranulin (GRN) Expression Promotes Lysosome-dependent Cell Death to Suppress Leukemogenesis

Meng Su, Qinglin Li, Zhiyi Lv, Xinshu Xie, Yating Lu, Yaohui He, Hanqi Liu, Hui Cao, Jie Ouyang, Qiao Zhang, Xuezhen Ma, Yexin Yang, Ailing Zou, Kang Liu (423471), Shuqian Xu, , Yang Mei

This study shows that inhibiting FASN leads to lysosome-dependent cell death via GRN expression, suppressing leukemogenesis in myeloid leukemia.

Cell Reports · Mar 1, 2026Peer-reviewedCancer Biology

ERAD Activity Distinguishes the Functional Heterogeneity of Hematopoietic Stem Cells

Qinlu Peng, Manxi Zheng, Suxuan Liu, Xinshu Xie, Zhejuan Shen, Ting Wang, Hanqi Liu, Wenbin Mi, Jie Zhou, Xuezhen Ma, Zhenyou Yin, Yuhan Hu, Guojun Shi, Yewei Ji, Dingxiao Zhang, , Lu Liu

This study identifies ERAD activity as a predictive and heritable marker of hematopoietic stem cell function by linking cytokine signaling to proteostasis remodeling.

bioRxiv · Dec 5, 2025 · PreprintCell Biology

PERK Signaling Maintains Hematopoietic Stem Cell Pool Integrity under Endoplasmic Reticulum Stress by Promoting Proliferation

Manxi Zheng, Qinlu Peng, Erin M. Kropp, Zhejuan Shen, Suxuan Liu, Zhengyou Yin, Sho Matono, Takao Iwawaki, Xiang Wang, Ken Inoki, Yang Mei, Qing Li, Lu Liu

This study shows PERK signaling promotes HSC proliferation under ER stress to maintain stem cell pool integrity by activating mTOR, without relying on apoptosis.

Blood · May 28, 2025Peer-reviewedCell Biology