Author

Takao Iwawaki

Kanazawa Medical UniversityORCID 0000-0001-8753-1979Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alexander EmmanuelliiD· 1 shared Alexandra Rusanova· 1 shared Andrew G. NewmaniD· 1 shared Bo QiniD· 1 shared Camilla SalvagnoiD· 1 shared Chang-Suk ChaeiD· 1 shared Chen TaniD· 1 shared Christian M. T. SpahniD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Alexander EmmanuelliORCID

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3 papers

Recent·Most cited

Cell BiologyBloodPeer-reviewedMay 28, 2025

PERK Signaling Maintains Hematopoietic Stem Cell Pool Integrity under Endoplasmic Reticulum Stress by Promoting Proliferation

Manxi Zheng, Qinlu Peng, Erin M. Kropp…·Lu Liu

This study shows PERK signaling promotes HSC proliferation under ER stress to maintain stem cell pool integrity by activating mTOR, without relying on apoptosis.

10 citationstop 3%

mouseexperimental assay

𝕏 PostBluesky

ImmunologyOncoImmunologyPeer-reviewedOct 2, 2024

High-grade serous ovarian cancer development and anti-PD-1 resistance is driven by IRE1α activity in neutrophils

Alexander Emmanuelli, Camilla Salvagno, Sung‐Min Hwang…·Juan R. Cubillos‐Ruiz

This study shows that IRE1α activity in neutrophils drives HGSOC development and anti-PD-1 resistance by promoting immune escape.

24 citationstop 4%

mouseexperimental assay

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NeuroscienceNature CommunicationsPeer-reviewedJun 7, 2024

Ire1α-Regulated mRNA Translation Rate Controls the Identity and Polarity of Upper Layer Cortical Neurons

Ekaterina V. Borisova, Andrew G. Newman, Marta Couce-Iglesias…·Mateusz C. Ambrozkiewicz

The paper shows that Ire1α regulates mRNA translation rates, which control the identity and polarity of upper layer cortical neurons through eIF4A1 and eEF-2.

28 citationstop 4%

mousebulk RNA-seq

𝕏 PostBluesky