Direct in vivo mapping of functional suppressors in glioblastoma genome
Ryan Dz-Wei Chow, Christopher D. Guzman, Guangchuan Wang, Florian Schmidt, Mark W. Youngblood, Lupeng Ye, Youssef Errami, Matthew B. Dong, Michael A. Q. Martinez, Sensen Zhang, Paul A. Renauer, Kaya Bilgüvar, Murat Günel, Phillip A. Sharp, Feng Zhang, , Sidi Chen
This study uses an AAV-mediated CRISPR screen in mice to identify functional suppressors of glioblastoma, revealing novel and canonical tumor suppressors and their interactions.
bioRxiv · Jun 22, 2017 · PreprintSystems Biology