Author
Matthew B. Dong
Systems Biology InstituteORCID 0000-0003-2553-5186Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2017-2024 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 30 mutual co-author links5 papers
Recent·Most cited
- BioengineeringbioRxivPreprintDOI 10.1101/2024.03.14.585126
- GeneticsbioRxivPreprint
Cas12a/Cpf1 knock-in mice enable efficient multiplexed immune cell engineering
Matthew B. Dong, Kaiyuan Tang, Xiaoyu Zhou…·Sidi Chen
The paper demonstrates efficient multiplexed gene editing in immune cells using Cas12a/Cpf1 knock-in mice and associated viral vectors.
5 citations - Molecular BiologyMolecular CellPeer-reviewed
Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA.
Shuai Yuan, Lei Peng, Jonathan Joon-Young Park…·Yong Xiong
This study identifies Nsp1 as a key pathogenicity factor of SARS-CoV-2 that redirects host translation machinery to viral RNA by inhibiting cellular protein synthesis and altering gene expression programs.
177 citationstop 1% - Systems BiologybioRxivPreprint
Pooled AAV-CRISPR Screen with Targeted Amplicon Sequencing
Guangchuan Wang, Ryan Dz-Wei Chow, Lupeng Ye…·Sidi Chen
The paper introduces PASTAS, a method for in vivo CRISPR screening in mice, and demonstrates its use in identifying cancer driver variants in liver tumors.
1 citation - Systems BiologybioRxivPreprint
Direct in vivo mapping of functional suppressors in glioblastoma genome
Ryan Dz-Wei Chow, Christopher D. Guzman, Guangchuan Wang…·Sidi Chen
This study uses an AAV-mediated CRISPR screen in mice to identify functional suppressors of glioblastoma, revealing novel and canonical tumor suppressors and their interactions.
DOI 10.1101/153460