Paul A. Renauer

Spatially Resolved in vivo CRISPR Screen Sequencing via Perturb-DBiT

Perturb-DBiT co-sequences spatial transcriptomes and gRNAs on one tissue section, supporting genome-wide in vivo CRISPR screens in FFPE and fresh-frozen tumors across three cancer models.

Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy

The paper identifies actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy through genome-scale CRISPR screens in melanoma cells.

Direct in vivo mapping of functional suppressors in glioblastoma genome

This study uses an AAV-mediated CRISPR screen in mice to identify functional suppressors of glioblastoma, revealing novel and canonical tumor suppressors and their interactions.