Author

Uma M. Sachdeva

Harvard UniversityORCID 0000-0002-0442-3794Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Aleigha R. LawlessiD· 1 shared Amanda B. MuiriD· 1 shared Andres J. Klein–SzantoiD· 1 shared Angelina M. CicerchiaiD· 1 shared Anuraag S. ParikhiD· 1 shared Arnav MehtaiD· 1 shared Aya Tal-masoniD· 1 shared Baolin LiuiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Aleigha R. LawlessORCID

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Author profile →

2 papers

Recent·Most cited

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy

Or‐Yam Revach, Angelina M. Cicerchia, Ofir Shorer, Claire A. Palin, Boryana Petrova, Seth Anderson, Baolin Liu, Joshua C. Park, Lee Chen, Arnav Mehta, Samuel J. Wright, Niamh McNamee, Aya Tal-mason, Giulia Cattaneo, Payal Tiwari, , Russell William Jenkins

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

Cell Reports Medicine · Jun 27, 2025Peer-reviewedCancer Biology

Modeling epithelial homeostasis and perturbation in three-dimensional human esophageal organoids

Masataka Shimonosono, Masaki Morimoto, Wataru Hirose, Yasuto Tomita, Norihiro Matsuura, Samuel P. Flashner, Mesra S. Ebadi, Emilea H. Okayasu, Christian Y. Lee, William R. Britton, Cecilia Martin, Beverly R. K. Wuertz, Anuraag S. Parikh, Uma M. Sachdeva, Frank G. Ondrey, , Hiroshi Nakagawa

This study optimizes ADF-based medium for normal human esophageal organoids and models pathological changes using inflammatory and pharmacological stimuli.

Biomolecules · Sep 5, 2024Peer-reviewedCell Biology