Author

Claudette R. Fraire

The University of Texas Southwestern Medical CenterORCID 0000-0002-0473-4541Unclaimed ORCID profile · follow to get notified of new preprints

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Indumathy JagadeeswaraniD· 1 shared Jeon LeeiD· 1 shared Kavita K. DesaiiD· 1 shared Kenan OneliD· 1 shared Kenneth Sung-Man CheniD· 1 shared Lindsay K. Mendyka· 1 shared Stephen X. SkapekiD· 1 shared Teja Sebastian· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Indumathy JagadeeswaranORCID

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1 paper

Recent·Most cited

An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma

Claudette R. Fraire, Kavita K. Desai, Indumathy Jagadeeswaran, Uma A Obalapuram, Lindsay K. Mendyka, Veena Rajaram, Teja Sebastian, Yemin Wang, Kenan Onel, Jeon Lee, Stephen X. Skapek, Kenneth Sung-Man Chen

This study shows that loss of microRNA processing genes leads to tumor development by disrupting proliferation and differentiation balance, and suggests targeting downstream drivers could be therapeutic.

bioRxiv · Apr 23, 2024Cancer Biology