Jeon Lee

Mitochondrial perturbation adapts the proteome from early to advanced immune responses

The paper shows mitochondrial state influences protein-level immune responses, with OXPHOS supporting early immune proteins and mitochondrial perturbation favoring inflammatory mediators in mice.

Interorganelle competition for linoleic acid underlies steatotic liver pathology

This study identifies CLSTN3B as a driver of MASLD by promoting LD biogenesis and altering lipid partitioning between LDs and mitochondria, leading to mitochondrial dysfunction and oxidative stress.

Hepatocyte-specific CLSTN3B ablation impairs lipid droplet maturation and alleviates diet-induced steatohepatitis in mice

This study shows that CLSTN3B promotes lipid droplet maturation in hepatocytes and that its deletion reduces steatohepatitis in mice, with a positive correlation between CLSTN3B expression and MASLD severity in humans.

Caveolin-1 regulates context-dependent signaling and survival in Ewing Sarcoma.

This study identifies Caveolin-1 as a context-dependent regulator of survival signaling in Ewing Sarcoma, revealing a reversible CD99High state with enhanced survival.

An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma

This study shows that loss of microRNA processing genes leads to tumor development by disrupting proliferation and differentiation balance, and suggests targeting downstream drivers could be therapeutic.

An integrated genomics approach towards deciphering human genome codes shaping HIV-1 proviral transcription and fate

The paper uses integrated genomics data to identify chromatin states and nuclear compartments influencing HIV-1 proviral transcription and fate.