Cancer BiologybioRxiv
An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma
Claudette R. Fraire, Kavita K. Desai, Indumathy Jagadeeswaran…·Kenneth Sung-Man Chen
This study shows that loss of microRNA processing genes leads to tumor development by disrupting proliferation and differentiation balance, and suggests targeting downstream drivers could be therapeutic.
7 citations