Author

Stephen X. Skapek

Duke UniversityORCID 0000-0002-4136-8384Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Jeon LeeiD· 2 shared Averi Perny· 1 shared Bingying CheniD· 1 shared Bo-Jui ChangiD· 1 shared Claudette R. FraireiD· 1 shared Dagan SegaliD· 1 shared Dana Kim ReediD· 1 shared Diego H. CastrillóniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Jeon LeeORCID

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Author profile →

2 papers

Recent·Most cited

Caveolin-1 regulates context-dependent signaling and survival in Ewing Sarcoma.

Dagan Segal, Xiaoyu Wang, Hanieh Mazloom-Farsibaf, Felix Y. Zhou, Divya Rajendran, Erin B. Butler, Bingying Chen, Bo-Jui Chang, Khushi Ahuja, Averi Perny, Kushal Bhatt, Dana Kim Reed, Diego H. Castrillón, Jeon Lee, Elise C. Jeffery, , Gaudenz M. Danuser

This study identifies Caveolin-1 as a context-dependent regulator of survival signaling in Ewing Sarcoma, revealing a reversible CD99High state with enhanced survival.

bioRxiv · Sep 23, 2024 · PreprintCancer Biology

An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma

Claudette R. Fraire, Kavita K. Desai, Indumathy Jagadeeswaran, Uma A Obalapuram, Lindsay K. Mendyka, Veena Rajaram, Teja Sebastian, Yemin Wang, Kenan Onel, Jeon Lee, Stephen X. Skapek, Kenneth Sung-Man Chen

This study shows that loss of microRNA processing genes leads to tumor development by disrupting proliferation and differentiation balance, and suggests targeting downstream drivers could be therapeutic.

bioRxiv · Apr 23, 2024Cancer Biology