Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol
Xin Zhou, Miesje M. van der Stoel, Shreyas Kaptan, Haoran Li, Shiqian Li, Maarit Hölttä‐Vuori, Helena Vihinen, Eija Jokitalo, Christoph Thiele, Olli P. H. Pietiläinen, Shin Morioka, Junko Sasaki, Takehiko Sasaki, Ilpo Vattulainen, Elina Ikonen
This study shows that Sac1 regulates Golgi V-ATPase assembly by controlling TGN membrane composition through lipid exchange, leading to Golgi fragmentation and impaired glycosylation.
Nature Communications · Aug 21, 2025Peer-reviewedCell Biology